Ketamine Therapy
Discover Mental Clarity + Emotional Stability
We offer a variety of Ketamine treatment options to best meet your treatment diagnosis, medical history, and mental health goals.
Experience the difference with Ketamine Therapy at Santa Cruz CORE.
In-person, virtual, and phone consultations available.
*We start with a comprehensive ketamine care assessment before any IM, IV, or Spravato treatment, and then guide you through a personalized ketamine journey followed by dedicated therapy sessions to integrate and support your results.
Ketamine Plus IV Infusion
Santa Cruz CORE is excited to offer Ketamine Plus IV Infusion, a revolutionary advancement in ketamine treatment that enhances the brain’s natural ability to heal. Unlike standard ketamine treatments, IV Infusion allows for highly controlled, adjustable dosage, and incorporates a proprietary blend of essential amino acids and nutrients to enhance neuroplasticity.
IV Ketamine has a slow release time of up to 1 hour, and patients typically feel a gradual, gentle effect that creates space for talk therapy or guidance throughout the treatment, if desired.
Ketamine Plus is not a one-size-fits-all treatment. Our team provides targeted dosing based on your treatment diagnosis, genetics, lab results, and consideration of any potential medication interactions. Whatever your treatment goals may be, we are dedicated to providing compassionate, effective care for mental health and addiction recovery.
Intramuscular (IM) Ketamine
Here at Santa Cruz CORE, we also offer intramuscular Ketamine as an effective and evidence-based treatment option.
Intramuscular ketamine works by injecting a controlled dosage of Ketamine into the patient’s muscle, typically a shoulder or thigh. IM Ketamine has a rapid onset, and patients may have a stronger, more immersive effect.
Troches
Troches are small, dissolvable ketamine lozenges placed under the tongue or in the cheek that slowly absorb through the mouth’s tissues rather than through an IV or injection. They offer a convenient, non-invasive option for ongoing or at-home ketamine-assisted treatment, helping support mood, reduce symptoms of conditions like depression or anxiety, and enhance therapeutic work under the guidance of a prescribing clinician.
Troches is via prescription and requires one of the following: in-person, video, or phone appointment with the physician. Call 831.425.9500 to see what works for you.
Spravato / Esketamine
Spravato is an FDA-approved esketamine nasal spray for treatment-resistant depression and major depressive disorder with active suicidal ideation. Administered in-office under medical supervision, it offers a clinically proven alternative for those who haven’t found relief through traditional antidepressants. Sessions take place in a comfortable, monitored setting at CORE, with most patients completing treatment in under two hours.
We can take insurance for Spravato! Call 831.425.9500 to see if your insurance will work with us.
*We start with a comprehensive ketamine care assessment before any IM, IV, or Spravato treatment, and then guide you through a personalized ketamine journey followed by dedicated therapy sessions to integrate and support your results.
Treatable Conditions
- Multi-Drug Resistant Depression
- Treatment Resistant Anxiety Disorders
- Post-Traumatic Stress Disorder (PTSD)
- Recovery from Substance Use and Other Addictions
- Obsessive-Compulsive Disorder (OCD)
Benefits of
Ketamine Plus
- Cognitive function enhancement
- Neuroplasticity and brain repair
- Mood stabilization and emotional resilience
- Reduction in inflammation and oxidative stress
Sublingual Ketamine
If Ketamine Infusions are not for you, we also offer sublingual treatment with Ketamine troches. A troche, or sublingual lozenge, can be a great non-invasive option for harnessing the benefits of Ketamine therapy.
Enjoy deep healing with ketamine therapy from the comfort of your home or your preferred safe, peaceful environment. At-home treatment is followed up with in-person visits to determine your ideal dosage and frequency for safe, effective treatment.
Meet Our Doctors
Dr. Eugene Santillano
Ketamine Plus IV Infusion Therapy
Dr. John Grady, D.O.
Ketamine Troches / Sublingual Treatments
Dr. Eugene Santillano is an expert dual-certified in Addiction and Family Medicine. He has over two decades of frontline primary care experience and ten years dedicated to guiding patients through the complexities of addiction recovery. He is committed to breaking barriers in addiction treatment by expanding access to compassionate guidance and evidence-based care through remote consultations.
Dr. Santillano specializes in personalized Medication for Addiction Treatment (MAT) and is proud to provide cutting-edge therapies, including Ketamine Treatment, to support mental health recovery. His unwavering mission is to challenge stigma, reduce implicit bias in healthcare, and empower patients and providers with the tools they need for compassionate transformation.
He has published the first of a series of books designed to reshape the conversation around addiction and mental health. Trauma-informed care means creating a treatment environment where individuals receive the recovery care they deserve—without judgment, with compassion and hope.
Ketamine is a unique medicine in mental health in that its safety and efficacy for severe depression and Suicidal ideation have been unmatched. It is the only medication that the National Institute of Mental Health has identified as a Rapidly Acting Anti Depressant (RAAD), and since initial off-label trials using ketamine, no other medicine has been able to replicate the safety and efficacy of ketamine.
Dr Santillano is a Certified Ketamine PLUS provider for Mental Health Treatment through the Ketamine Research Institute and has completed additional training with Dr. Phil Wolfson, the intellectual leader in Ketamine-Assisted Psychotherapy.
Dr. John Grady graduated from the Midwestern University, Arizona College of Osteopathic Medicine in 2008. He now works in Santa Cruz County, California specializing in Emergency Medicine, Osteopathy, and Rejuventation Therapies.
Dr. Grady is a Board Certified Emergency Medicine Osteopathic physician at Dominican Hospital in Santa Cruz, CA. Dr. Grady has received advanced Prolotherapy training from the Hackett Hemwell Patterson Foundation (HHP), and performs Prolotherapy, Platelet Rich Plasma (PRP), and Stem Cell injections for therapeutic and cosmetic procedures.
He volunteers in Honduras performing rejuvenation injection therapy on locals in clinics, which HHP has been staffing since 1969. At HHP, he also administers Osteopathic Manipulative Therapy and sports medicine treatment to patients. Dr. Grady is also an adjunct Professoor at Touro Univeristy’s medical school.
In addition, Dr. Grady has worked at Dominican Hospital’s ER since 2011 treating thousands of Santa Cruz natives suffering from trauma, sports injuries, infections, acute complications of chronic conditions, and much more. He co-created Heart Farm in Soquel with his partner, Samantha Matthews.
Dr. Grady specializes in Regenerative Medicine, and is proud to provide cutting-edge treatments, including Ketamine Troches, to support mental health recovery.
Do you live in the Santa Cruz or Watsonville area?
Call 831-425-9500 or email info@santacruzcore.com and mention this page to redeem!
*Photo ID required
Schedule Your Free Consultation
If you still have any unanswered questions feel free to call us or email and we will be sure to get back to you as soon as possible. Excited to hear from you!