Ketamine Therapy
Experience the Transformative Power of Ketamine Plus at Santa Cruz Core
Santa Cruz Core is proud to introduce Ketamine Plus Therapy, an innovative and science-backed approach to mental wellness and chronic pain relief. Utilizing the Restore Ketamine Plus Infusion, this advanced treatment goes beyond traditional ketamine therapy by incorporating a proprietary blend of essential amino acids and nutrients to enhance neuroplasticity, support cellular health, and optimize results. Whether you are seeking relief from depression, anxiety, or PTSD, our expert team is dedicated to guiding you on a personalized journey toward healing and transformation.
With a focus on whole-body wellness, Ketamine Plus Therapy at Santa Cruz Core is designed to restore balance, improve resilience, and accelerate recovery. By harnessing the latest breakthroughs in neuroscience and regenerative medicine, we provide a comprehensive, evidence-based solution for those who have struggled with conventional treatments. Discover a new path to mental clarity, emotional stability, and physical well-being—experience the difference with Ketamine Plus Therapy at Santa Cruz Core.
In-person, virtual, and phone consultations available.
Core is Best
Comprehensive, Whole-Body Approach
Santa Cruz Core goes beyond traditional ketamine therapy by integrating Ketamine Plus, a cutting-edge infusion that combines ketamine with essential amino acids and nutrients to enhance neuroplasticity and cellular healing. Unlike other clinics that focus solely on symptom relief, our approach is designed to support long-term wellness, helping you achieve lasting mental and physical balance. By combining ketamine therapy with our expertise in integrative medicine, we provide a more complete and effective treatment experience.
Personalized Care in a Supportive Environment
At Santa Cruz Core, we prioritize individualized care, tailoring each Ketamine Plus treatment plan to meet your unique needs and wellness goals. Our experienced team takes the time to understand your health history and recovery journey, ensuring a compassionate and customized approach that other clinics often overlook. With a focus on patient comfort and safety, we create a warm, welcoming environment where you can heal with confidence.
A Leader in Holistic Health and Innovation
With years of experience in functional medicine and holistic wellness, Santa Cruz Core is uniquely positioned to offer ketamine therapy as part of a broader, science-backed healing plan. Unlike clinics that specialize only in ketamine infusions, we integrate multiple modalities—such as physical therapy, chiropractic care, and nutrition—to amplify your results. Our commitment to innovation and whole-body health makes us the premier choice for those seeking deeper, more sustainable healing.
Ketamine Plus
Santa Cruz CORE is excited to offer Ketamine Plus Therapy, a revolutionary advancement in ketamine treatment that enhances the brain’s natural ability to heal. Unlike standard ketamine infusions, Ketamine Plus incorporates a proprietary blend of essential amino acids and metabolic cofactors designed to maximize ketamine’s neuroplastic effects. This unique formula not only accelerates recovery from depression, anxiety, and PTSD symptoms, but also promotes long-term cellular repair, making it a more effective and lasting solution than conventional ketamine therapies.
What sets Ketamine Plus Therapy apart is its ability to restore and optimize brain function, rather than just providing temporary symptom relief. Traditional ketamine treatments focus solely on short-term mood improvement, while Ketamine Plus works at a deeper level, enhancing neurogenesis and cellular metabolism for more profound and sustained results.
At CORE, Ketamine Plus Therapy is not a one-size-fits-all treatment—it is a custom-tailored approach designed to meet each patient’s unique needs. Our expert practitioners carefully evaluate your medical history, symptoms, and wellness goals to develop a personalized plan that optimizes your results. Unlike traditional ketamine treatments, which follow a standardized protocol, Ketamine Plus is adjusted based on individual response, ensuring the right balance of ketamine, amino acids, and metabolic cofactors for maximum healing and long-term benefits. Whatever your treatment goals may be, our personalized approach ensures you receive the most effective and comprehensive care available.
Ketamine Plus Therapy at CORE is designed to treat a wide range of mental health conditions, including:

Mental Health Conditions
- Depression (including treatment-resistant depression)
- Anxiety disorders
- Post-Traumatic Stress Disorder (PTSD)
- Bipolar disorder (depressive phase)
- Obsessive-Compulsive Disorder (OCD)
- Suicidal ideation
Additional Benefits
- Cognitive function enhancement
- Neuroplasticity and brain repair
- Mood stabilization and emotional resilience
- Reduction in inflammation and oxidative stress
Meet Our Doctors
Dr. Eugene Santillano is an expert dual-certified in Addiction and Family Medicine. He has over two decades of frontline primary care experience and ten years dedicated to guiding patients through the complexities of addiction recovery. He is committed to breaking barriers in addiction treatment by expanding access to compassionate guidance and evidence-based care through remote consultations.
Dr. Santillano specializes in personalized Medication for Addiction Treatment (MAT) and is proud to provide cutting-edge therapies, including Ketamine Treatment, to support mental health recovery. His unwavering mission is to challenge stigma, reduce implicit bias in healthcare, and empower patients and providers with the tools they need for compassionate transformation.
He has published the first of a series of books designed to reshape the conversation around addiction and mental health. Trauma-informed care means creating a treatment environment where individuals receive the recovery care they deserve—without judgment, with compassion and hope.
Ketamine is a unique medicine in mental health in that its safety and efficacy for severe depression and Suicidal ideation have been unmatched. It is the only medication that the National Institute of Mental Health has identified as a Rapidly Acting Anti Depressant (RAAD), and since initial off-label trials using ketamine, no other medicine has been able to replicate the safety and efficacy of ketamine.
Dr Santillano is a Certified Ketamine PLUS provider for Mental Health Treatment through the Ketamine Research Institute and has completed additional training with Dr. Phil Wolfson, the intellectual leader in Ketamine-Assisted Psychotherapy.
Do you live in the Santa Cruz or Watsonville area?

Call 831-425-9500 or email info@santacruzcore.com and mention this page to redeem!
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Start on Your Wellness Journey Today!
If you still have any unanswered questions feel free to call us or email and we will be sure to get back to you as soon as possible. Excited to hear from you!